Overview of Selected Chemical Compounds and Intermediates

Overview of Selected Chemical Compounds and Intermediates

Blog Article

one. Pharmaceutical Intermediates
Bortezomib Acid Impurity: This can be an impurity connected with bortezomib, a proteasome inhibitor Utilized in the cure of various myeloma. Its synthesis or review is very important for ensuring the purity and basic safety in the drug.
Abiraterone Acetate Intermediate (CAS NO. 122111-01-seven): A precursor from the synthesis of abiraterone acetate, a drug Utilized in the remedy of prostate cancer by inhibiting androgen generation.
Imatinib Intermediate (CAS NO. 152460-ten-1): A critical compound during the synthesis of imatinib, a drug that targets distinct varieties of cancer, including Serious myelogenous leukemia (CML).
Docetaxel Intermediate: A compound Utilized in the synthesis of docetaxel, a chemotherapy medication that treats a variety of cancers which include breast, lung, and prostate most cancers.
two. Chemical Impurities and Byproducts
GeMcitabine Intermediates (T6, T9, 8): They're intermediates within the synthesis of gemcitabine, an anti-most cancers drug. Their study is important for optimizing the generation procedure and making sure superior purity.
Lapatinib Intermediate (CAS NO. 231278-eighty four-five): Lapatinib is employed to deal with breast most cancers, and these intermediates are involved in its creation.
Fulvestrant Intermediates: Fulvestrant can be an estrogen receptor antagonist used in the remedy of breast most cancers. Various intermediates help in the synthesis of the drug.
Paclitaxel Side Chain Acid (CAS NO. 949023-16-9): This intermediate is Employed in the synthesis of paclitaxel, a chemotherapy drug efficient in dealing with cancers for instance 3-d]pyriMidin-7(8H)-one ovarian, breast, and lung most cancers.
three. Other Noteworthy Compounds
Irinotecan Hydrochloride Trihydrate (CAS NO. 136572-09-three): A chemotherapy drug Employed in the remedy of colorectal most cancers and compact cell lung cancer.
3-Amino-one-hydroxyadamantane (CAS 702-eighty two-nine): This compound is linked to the synthesis of adamantane derivatives, that have numerous apps, including antiviral Qualities.
Vildagliptin Intermediates: Utilized in the manufacture of vildagliptin, an oral drug for type 2 diabetic issues that inhibits the enzyme DPP-four to control blood sugar concentrations.
four. Miscellaneous Compounds
D-Gluconic Acid δ-Lactone (CAS NO. 61259-forty eight-1): This compound is associated with the synthesis of varied gluconic acid derivatives, which might be Employed in food items, pharmaceutical, and industrial apps.
Canagliflozin Intermediate 2: A precursor while in the 2-Deoxy-2 synthesis of canagliflozin, a medication utilised to control variety 2 diabetes by inhibiting sodium-glucose co-transporter two (SGLT2).